Adpt-MEA2
Overview
MEA (Microelectrode Array) is a simplified electrophysiological signal recording system designed to streamline the electrophysiological recording process. Its design allows users to conveniently swap different types of microelectrode array chips based on specific experimental requirements.
- Record electrical signals from multiple sites within the culture.
- Replicate the biophysical microenvironment found in vivo.
MEA2 Overview
Dimension
unit: mm
Device Overview
In vitro experiments often struggle to replicate the cellular conditions found in living organisms. Primary cells cultured on rigid multi-electrode arrays (MEAs) exhibit significant differences from their in vivo counterparts, limiting the predictive value of such data. MEAs utilize glass multi-electrode arrays to recreate the mechanical and electrical environments of in vivo cells in a controlled setting. They can be paired with various headstages and stimulation array boards for optical imaging and electrical stimulation/recording, effectively bridging the gap between in vitro and in vivo research and enhancing the relevance of experimental findings.
Assembly Process
① Remove the ITO conductive glass
② Remove the silicone gasket
③ Unscrew the six anti-loosening thumb screws
④ Separate the top and bottom housings
⑤ Remove and replace the MEA cup
Key Features
- Flexibility: Compatible with various brands and types of microelectrode array chips, enabling users to choose according to their experimental needs.
- Efficiency: The simplified system design enhances the efficiency of electrophysiological signal recording, reducing preparation time for experiments.
- Data Precision: MEA captures neuronal activity and electrophysiological signals between cells with high accuracy, facilitating further analysis and research.
- User-Friendly: The interface is designed to be intuitive, suitable for researchers of varying experience levels.
- Scalability: The system can be expanded as needed, allowing for the addition of more channels to record additional signals.
Experimental Applications
- Neuroscience Research: Used to study interactions between neurons.
- Biomedical Research: Employed in drug testing and research on neurological disorders.
- Immunology:
Applicable for investigating cellular signaling and interactions.
The flexibility and efficiency of MEA make it an essential tool in many biomedical research applications.
MEA Cup
MEA2 supports a range of MEA cup sizes, with a maximum supported size of 59.9 × 59.9 mm.
unit: mm
Ground & Reference Configuration
- To connect reference and ground at the adapter, short JP1.
- Ground (G) is sourced from the probe ground (PG). To use an external ground (EG) via the adapter, cut JP2 and solder a wire to the EG pad.
- Reference (R) is sourced from the probe reference (PR). To use an external reference (ER) via the adapter, cut JP3 and solder a wire to the ER pad.
- Shielding (S) is connected by default to ground (G). To use an external shielding signal (ES) via the adapter, cut JP4 and solder a wire to the ES pad.
- The adapter’s metal rod is electrically isolated from the headstage. To connect it to the adapter’s shielding, short JP5.
Configuring the Jumper Pad
① To connect the jumper, apply solder around JP1 until a solid solder bead forms.
② To disconnect, use a soldering iron and desoldering mesh to remove the solder bridging the jumper pad.
If the jumper pas has a default short configuration, use a scalpel or precision blade to cleanly sever the trace.
④ Always verify connectivity using a multimeter to ensure proper configuration.
Pin Map
